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1.
(1 point)
In a zero order elimination process, which of the following is true?
The removal of drug is independent of drug concentration
Cl = Elimination rate/Cp
t1/2 = .7VD/Cl
All are true
2.
(1 point)
For highly polar drugs (e.g. mannitol) what primarily determines elimination rate?
Excretion rate
Metabolism rate
Absorption rate
Distribution rate
All of the above
3.
(1 point)
Bioavailability is related to which of the following parameters, according to the equation F = 1 - E
Excretion
Elimination
Extraction Ratio
Enterohepatic Recycling
4.
(1 point)
For the majority of drugs, which of the following equations correctly defines clearance?
Cl = Elimination rate/Cp
Cl = QxE
Cl = .7VD/t1/2
All are correct
5.
(1 point)
How much of a 10 mg dose of morphine reaches the systemic circulation given F = .24?
24mg
0.24 mg
2.4 mg
4.1 mg
6.
(1 point)
Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for morphine, approximately how much of a 10 mg IV dose remains after 8 hr, given to a normal 70 Kg patient?
5 mg
2.5 mg
1.25 mg
625 mg
7.
(1 point)
Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given in the previous question is entirely hepatic clearance.
30 L/hr/70 Kg
60 L/hr/70 Kg
120 L/hr/70 Kg
250 L/hr/70 Kg
8.
(1 point)
Which of the following enzymes could directly act on codeine?
Glucuronyl transferase
Sulfotransferase
Glutathione transferase
a & b
All of the above
9.
(1 point)
Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?
CYP1A2
CYP2C9
CYP3A4
CYP51
All are drug metabolizing isoforms
10.
(1 point)
Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?
CYP1A2
CYP2C9
CYP2D6
CYP3A4
CYP51
11.
(1 point)
Which of the following enzymes could metabolize ethanol?
Cytochrome P450
Alcohol Dehydrogenase
Glucuronyl Transferase
Sulfotransferase
All of the above
12.
(1 point)
Which of the following are similarities between Cytochrome P450 and MAO?
Both add oxygen from O2 to substrates and also form water
Both carry out direct heteroatom oxidations
Both carry out oxidative deaminations
Both carry out N-dealkylations
All of the above
13.
(1 point)
What would be the preferred route of metabolism of succinyl choline?
Ester hydrolysis
N-oxidation
Glucuronide conjugation
a & b
All of the above
14.
(1 point)
Which of the following causes the smallest change in solubility?
Hydroxylation
Glucuronidation
Sulfation
Glutathione conjugation
15.
(1 point)
Cigarette smoke causes an increase in levels of CYP1A isozymes. Theophylline is primarily metabolized by the CYP1A system. What would happen to theophylline clearance for an asthmatic patient in hospital who could not smoke?
No change
Increase
Decrease
US